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AMIC® Chondro-Gide® Anca

Defeitos condrais no quadril causados por trauma, osteonecrose, lesão labral, e outras causas podem resultar em severa disfunção e dor articular. Impacto femoroacetabular é outra causa comum de lesões de cartilagem focais, necessitando de artroscopia de quadril1.

Postergar ou Evitar Prótese Total de Quadril é Agora Possível

A Cartilagem danificada possui capacidade limitada de se regenerar. Se não tratada, a lesão pode piorar ao longo do tempo. Com o tratamento artroscópico minimamente invasivo para lesões condrais no quadril, preservar a cartilagem da articulação do quadril e postergar ou possivelmente até mesmo evitar uma cirurgia de prótese total de quadril1 é agora possível.

AMIC® Chondro-Gide® para Regeneração de Cartilagem Eficaz

AMIC® Chondro-Gide® é um tratamento minimamente invasivo de um único tempo cirúrgico que utiliza estimulação medular em combinação com Chondro-Gide para reparar lesões condrais de todos os tamanhos.

Desenvolvida pela Geistlich Surgery em colaboração com cirurgiões pioneiros na Europa, AMIC® Chondro-Gide® é um tratamento eficaz e economicamente eficiente2,3 para tratar lesões no quadril, aliviando ou prevenindo a dor, e desacelerando a progressão da lesão.

Com sua estrutura de dupla face especialmente fabricada, Chondro-Gide® fornece um ambiente protetor que nutre o crescimento de nova cartilagem.4,5

  • Membrana de colágeno tipo I/III de dupla face, bio-derivada1.
  • Biocompatível e naturalmente reabsorvida1.
  • Fixação com cola de fibrina ou sutura4.
  • Compatível com diversas técnicas de regeneração de cartilagem5.
  • Procedimento de um único tempo cirúrgico1.
  • Fácil manuseio: flexível e resistente1.
  • Pronto para uso imediato, estéril.

References

  1. MARQUEZ-LARA, A. et al., 2016, Arthroscopic Management of Hip Chondral Defects: A Systematic Review of the Literature. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2016. Vol. 32, no. 7, p. 1435-1443. DOI 10.1016/j.arthro.2016.01.058. Elsevier BV (Review).
  2. SCHIAVONE PANNI, A., et al. Good clinical results with autologous matrix-induced chondrogenesis (AMIC) technique in large knee chondral defects. Knee Surg Sports Traumatol Arthrosc, 2018 Apr 26(4):1130-36 (Clinical study).
  3. WALTHER, M., et al. Scaffold based reconstruction of focal full thickness talar cartilage defects. Clinical Research on Foot & Ankle, 2013, 1-5. (Clinical study).
  4. Geistlich Pharma AG data on file (Pre-clinical Study)
  5. GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
  6. KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006,  3(5), 616-626. (Clinical study)
  7. FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
  8. DE GIROLAMO, L., et al., Autologous Matrix-Induced Chondrogenesis (AMIC) and AMIC Enhanced by Autologous Concentrated Bone Marrow Aspirate (BMAC) Allow for Stable Clinical and Functional Improvements at up to 9 Years Follow-Up: Results from a Randomized Controlled Study. Journal of Clinical Medicine. 2019. Vol. 8, no. 3, p. 392. DOI 10.3390/jcm8030392. MDPI AG (Clinical Study)
  9. Chondro-Gide® IFU 2019, Geistlich Pharma AG
  10. FICKERT, S. et al., 2017, Biologic Reconstruction of Full Sized Cartilage Defects of the Hip: A Guideline from the DGOU Group “Clinical Tissue Regeneration” and the Hip Committee of the AGA. Zeitschrift für Orthop.die und Unfallchirurgie. 2017. Vol. 155, no. 06, p. 670-682. DOI 10.1055/s-0043-116218. Georg Thieme Verlag KG (Guideline).
  11. FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
  12. KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study).
  13. DE GIROLAMO, L., et al., 2018, Acetabular Chondral Lesions Associated With Femoroacetabular Impingement Treated by Autologous Matrix-Induced Chondrogenesis or Microfracture: A Comparative Study at 8-Year Follow-Up. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2018. Vol. 34, no. 11, p. 3012-3023. DOI 10.1016/j.arthro.2018.05.035. Elsevier BV (Clinical study).
  14. MANCINI, D., and FONTANA, A., 2014, Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement. International Orthopaedics. 2014. Vol. 38, no. 10, p. 2057-2064. DOI 10.1007/s00264-014-2403-1. Springer Science and Business Media LLC (Clinical study).

Técnica AMIC® para o Quadril descrita por Dr. Fontana

Técnica AMIC® para o Quadril descrita por Dr. Andrea Fontana (Inglês)

Evidência clínica - AMIC® no anka

Como funciona o Chondro-Gide®

Chondro-Gide® fornece uma cobertura protetora e mantém no lugar as células liberadas pela estimulação medular do osso subcondral ou introduzidas dentro do defeito. É um complemento para tratamentos regenerativos para lesões condrais e osteocondrais. Enquanto mantém as células dentro do defeito nos estágios iniciais do processo de cicatrização, o Chondro-Gide® é reabsorvido aproximadamente entre 1 a 4 meses9 e é substituído por tecido novo.

Vantagens de Longo Prazo de AMIC® Chondro-Gide® vs. Micro Fraturas.

O uso do Chondro-Gide® no quadril está bem estabelecido. Dados de pós-operatório acima de 8 anos claramente demonstram as vantagens de longo prazo de AMIC® Chondro-Gide® comparado a micro fraturas isoladas nos defeitos acetabulares10,11,12. Em um estudo comparando micro fraturas com AMIC® Chondro-Gide®, De Girolamo et al.11,13 investigou 109 pacientes. Pacientes com defeitos condrais no quadril associados com impacto femoroacetabular, foram tratados com AMIC Chondro-Gide® ou micro fraturas. Não houve diferença significante de idade ou tamanho de lesão entre os dois grupos de pacientes.

References

  1. MARQUEZ-LARA, A. et al., 2016, Arthroscopic Management of Hip Chondral Defects: A Systematic Review of the Literature. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2016. Vol. 32, no. 7, p. 1435-1443. DOI 10.1016/j.arthro.2016.01.058. Elsevier BV (Review).
  2. SCHIAVONE PANNI, A., et al. Good clinical results with autologous matrix-induced chondrogenesis (AMIC) technique in large knee chondral defects. Knee Surg Sports Traumatol Arthrosc, 2018 Apr 26(4):1130-36 (Clinical study).
  3. WALTHER, M., et al. Scaffold based reconstruction of focal full thickness talar cartilage defects. Clinical Research on Foot & Ankle, 2013, 1-5. (Clinical study).
  4. Geistlich Pharma AG data on file (Pre-clinical Study)
  5. GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
  6. KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006,  3(5), 616-626. (Clinical study)
  7. FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
  8. DE GIROLAMO, L., et al., Autologous Matrix-Induced Chondrogenesis (AMIC) and AMIC Enhanced by Autologous Concentrated Bone Marrow Aspirate (BMAC) Allow for Stable Clinical and Functional Improvements at up to 9 Years Follow-Up: Results from a Randomized Controlled Study. Journal of Clinical Medicine. 2019. Vol. 8, no. 3, p. 392. DOI 10.3390/jcm8030392. MDPI AG (Clinical Study)
  9. Chondro-Gide® IFU 2019, Geistlich Pharma AG
  10. FICKERT, S. et al., 2017, Biologic Reconstruction of Full Sized Cartilage Defects of the Hip: A Guideline from the DGOU Group “Clinical Tissue Regeneration” and the Hip Committee of the AGA. Zeitschrift für Orthop.die und Unfallchirurgie. 2017. Vol. 155, no. 06, p. 670-682. DOI 10.1055/s-0043-116218. Georg Thieme Verlag KG (Guideline).
  11. FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
  12. KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study).
  13. DE GIROLAMO, L., et al., 2018, Acetabular Chondral Lesions Associated With Femoroacetabular Impingement Treated by Autologous Matrix-Induced Chondrogenesis or Microfracture: A Comparative Study at 8-Year Follow-Up. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2018. Vol. 34, no. 11, p. 3012-3023. DOI 10.1016/j.arthro.2018.05.035. Elsevier BV (Clinical study).
  14. MANCINI, D., and FONTANA, A., 2014, Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement. International Orthopaedics. 2014. Vol. 38, no. 10, p. 2057-2064. DOI 10.1007/s00264-014-2403-1. Springer Science and Business Media LLC (Clinical study).

AMIC® vs MACI®

Um estudo de 5 anos de Mancini e Fontana comparou os resultados das técnicas AMIC® Chondro-Gide® e MACI (Membrana + implante de condrócitos autólogos) para o tratamento de defeitos condrais acetabulares de tamanho médio.13 AMIC oferece benefícios adicionais pelo fato de ser um procedimento de único tempo cirúrgico, minimamente invasivo que pode reduzir o tempo de tratamento total e minimizar morbidade.

Para mais detalhes sobre técnicas cirúrgicas de Chondro-Gide® e insights clínicos, baixe o arquivo.

 

References

  1. MARQUEZ-LARA, A. et al., 2016, Arthroscopic Management of Hip Chondral Defects: A Systematic Review of the Literature. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2016. Vol. 32, no. 7, p. 1435-1443. DOI 10.1016/j.arthro.2016.01.058. Elsevier BV (Review).
  2. SCHIAVONE PANNI, A., et al. Good clinical results with autologous matrix-induced chondrogenesis (AMIC) technique in large knee chondral defects. Knee Surg Sports Traumatol Arthrosc, 2018 Apr 26(4):1130-36 (Clinical study).
  3. WALTHER, M., et al. Scaffold based reconstruction of focal full thickness talar cartilage defects. Clinical Research on Foot & Ankle, 2013, 1-5. (Clinical study).
  4. Geistlich Pharma AG data on file (Pre-clinical Study)
  5. GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
  6. KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006,  3(5), 616-626. (Clinical study)
  7. FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
  8. DE GIROLAMO, L., et al., Autologous Matrix-Induced Chondrogenesis (AMIC) and AMIC Enhanced by Autologous Concentrated Bone Marrow Aspirate (BMAC) Allow for Stable Clinical and Functional Improvements at up to 9 Years Follow-Up: Results from a Randomized Controlled Study. Journal of Clinical Medicine. 2019. Vol. 8, no. 3, p. 392. DOI 10.3390/jcm8030392. MDPI AG (Clinical Study)
  9. Chondro-Gide® IFU 2019, Geistlich Pharma AG
  10. FICKERT, S. et al., 2017, Biologic Reconstruction of Full Sized Cartilage Defects of the Hip: A Guideline from the DGOU Group “Clinical Tissue Regeneration” and the Hip Committee of the AGA. Zeitschrift für Orthop.die und Unfallchirurgie. 2017. Vol. 155, no. 06, p. 670-682. DOI 10.1055/s-0043-116218. Georg Thieme Verlag KG (Guideline).
  11. FONTANA, A. and DE GIROLAMO, L., 2015, Sustained 5-year benefit of autologous matrix-induced chondrogenesis for femoral acetabular impingement-induced chondral lesions compared with microfracture treatment. The Bone & Joint Journal. 2015. Vol. 97-B, no. 5, p. 628-635. DOI 10.1302/0301-620x.97b5.35076. British Editorial Society of Bone & Joint Surgery (Clinical study).
  12. KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study).
  13. DE GIROLAMO, L., et al., 2018, Acetabular Chondral Lesions Associated With Femoroacetabular Impingement Treated by Autologous Matrix-Induced Chondrogenesis or Microfracture: A Comparative Study at 8-Year Follow-Up. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2018. Vol. 34, no. 11, p. 3012-3023. DOI 10.1016/j.arthro.2018.05.035. Elsevier BV (Clinical study).
  14. MANCINI, D., and FONTANA, A., 2014, Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement. International Orthopaedics. 2014. Vol. 38, no. 10, p. 2057-2064. DOI 10.1007/s00264-014-2403-1. Springer Science and Business Media LLC (Clinical study).
Marcelo Roggembaum

National Sales Manager Surgery