Chondro-Gide®
Chondro-Gide® é uma membrana de colágeno tipo I/III, de dupla face, desenvolvida especificamente para a regeneração de cartilagem. Fabricada a partir de colágeno porcino altamente purificado, é produzida na Suíça seguindo um rigoroso processo de fabricação, assegurando sua segurança e qualidade.1
A função do Chondro-Gide® é alavancar o potencial de cura do organismo para regenerar a cartilagem humana. Com uma camada superior lisa, e uma camada inferior rugosa, sua estrutura proporciona as condições necessárias para a regeneração de cartilagem.
Benefícios
O sucesso do Chondro-Gide® é respaldado por mais de 10 anos de estudos clínicos2. Com sua estrutura de dupla face especialmente desenvolvida, Chondro-Gide® proporciona um ambiente protetor que nutre o crescimento de nova cartilagem.3,4
- Membrana de colágeno tipo I/III de dupla face, bio-derivada1.
- Biocompatível e naturalmente reabsorvida1.
- Fixação com cola de fibrina ou sutura4.
- Compatível com diversas técnicas de regeneração de cartilagem5.
- Procedimento de um único tempo cirúrgico1.
- Fácil manuseio: flexível e resistente1.
- Pronto para uso imediato, estéril.
References
- Geistlich Pharma AG data on file (Bench test)
- KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study)
- GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
- VOLZ, M., et al. A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. Int Orthop, Apr 2017, 41(4), 797-804. (Clinical study)
- KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006, 63(5), 616-626. (Clinical study)
- GOMOLL, A.H., Surgical Management of Articular Cartilage Defects of the Knee. J Bone Joint Surg Am. 2010;92:2470-90 (Clinical study)
- MUMME, M., Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. Lancet, 2016, 388 (10055) 1985-1994. (Clinical study)
- FULCO, I., et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet, Jul 26 2014, 84(9940), 337-346. (Clinical study)
- STEINWACHS, M.R., New Technique for Cell-Seeded Collagen Matrix-Supported Autologous Chondrocyte Transplantation, Arthroscopy: The Journal of Arthroscopic & Related Surgery Volume 25, Issue 2, February 2009, Pages 208-211 (Technical note)
- STEINWACHS, M. R., et al., "Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee." Cartilage 2019: 1947603519870846. (Review of clinical studies)
- CIEMNIEWSKA-GORZELA, K., et al.,Meniscus Tears Treated with Collagen Matrix Wrapping and Bone Marrow Blood Injection: Clinical Effectiveness and Survivorship after a Minimum of 5 Years’Follow-Up. Cartilage. 2020 Jun 1 (Clinical study)
Como funciona o Chondro-Gide®
References:
- Geistlich Pharma AG data on file (Bench test)
- KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study)
- GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
- VOLZ, M., et al. A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. Int Orthop, Apr 2017, 41(4), 797-804. (Clinical study)
- KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006, 63(5), 616-626. (Clinical study)
- GOMOLL, A.H., Surgical Management of Articular Cartilage Defects of the Knee. J Bone Joint Surg Am. 2010;92:2470-90 (Clinical study)
- MUMME, M., Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. Lancet, 2016, 388 (10055) 1985-1994. (Clinical study)
- FULCO, I., et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet, Jul 26 2014, 84(9940), 337-346. (Clinical study)
- STEINWACHS, M.R., New Technique for Cell-Seeded Collagen Matrix-Supported Autologous Chondrocyte Transplantation, Arthroscopy: The Journal of Arthroscopic & Related Surgery Volume 25, Issue 2, February 2009, Pages 208-211 (Technical note)
- STEINWACHS, M. R., et al., "Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee." Cartilage 2019: 1947603519870846. (Review of clinical studies)
- CIEMNIEWSKA-GORZELA, K., et al.,Meniscus Tears Treated with Collagen Matrix Wrapping and Bone Marrow Blood Injection: Clinical Effectiveness and Survivorship after a Minimum of 5 Years’Follow-Up. Cartilage. 2020 Jun 1 (Clinical study)
Técnicas cirúrgicas que utilizam Chondro-Gide®
Chondro-Gide® como transportador
Nas técnicas de implantação autóloga de condrócitos, o Chondro-Gide® serve como transportador. Fornece uma matriz de suporte 3D para adesão e diferenciação celular. As células podem ser semeadas no lado áspero da membrana de bicamada, enquanto o lado liso evita a perda de células durante o processo.
Chondro-Gide® como cobertura
AMIC® (Condrogênese Autóloga Induzida por Matriz) é uma técnica de passo único, econômica e eficaz para o tratamento de defeitos da cartilagem. No AMIC®, o Chondro-Gide® cobre o defeito e oferece um ambiente protetor para a diferenciação celular e a formação de nova cartilagem3,7,10. Saiba mais sobre o AMIC® aqui.
Chondro-Gide® como envoltório
AMMR® (Arthroscopic Matrix-Based Meniscus Repair) é uma técnica que foi desenvolvida para preservar o menisco. A membrana é enrolada ao redor do menisco lesado, com o lado liso voltado para a cavidade articular11. Em um estudo, o espaço entre o menisco e a membrana envolvente foi aumentado com fatores biológicos para melhorar o processo de reparo.
References
- Geistlich Pharma AG data on file (Bench test)
- KAISER, N., et al. Clinical results 10 years after AMIC in the knee. Swiss Med Wkly, 2015, 145 (Suppl 210), 43S. (Clinical study)
- GILLE, J., et al. Cell-Laden and Cell-Free Matrix-Induced-Chondrogenesis versus Microfracture for the Treatment of Articular Cartilage Defects: A Histological and Biomechanical Study in Sheep. Cartilage OnlineFirst, January 7, 2010, doi:10.1177/1947603509358721 (Pre-clinical study)
- VOLZ, M., et al. A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. Int Orthop, Apr 2017, 41(4), 797-804. (Clinical study)
- KRAMER, J., et al. In vivo matrix-guided human mesenchymal stem cells. Cell Mol Life Sci, Mar 2006, 63(5), 616-626. (Clinical study)
- GOMOLL, A.H., Surgical Management of Articular Cartilage Defects of the Knee. J Bone Joint Surg Am. 2010;92:2470-90 (Clinical study)
- MUMME, M., Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. Lancet, 2016, 388 (10055) 1985-1994. (Clinical study)
- FULCO, I., et al. Engineered autologous cartilage tissue for nasal reconstruction after tumour resection: an observational first-in-human trial. Lancet, Jul 26 2014, 84(9940), 337-346. (Clinical study)
- STEINWACHS, M.R., New Technique for Cell-Seeded Collagen Matrix-Supported Autologous Chondrocyte Transplantation, Arthroscopy: The Journal of Arthroscopic & Related Surgery Volume 25, Issue 2, February 2009, Pages 208-211 (Technical note)
- STEINWACHS, M. R., et al., "Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee." Cartilage 2019: 1947603519870846. (Review of clinical studies)
- CIEMNIEWSKA-GORZELA, K., et al.,Meniscus Tears Treated with Collagen Matrix Wrapping and Bone Marrow Blood Injection: Clinical Effectiveness and Survivorship after a Minimum of 5 Years’Follow-Up. Cartilage. 2020 Jun 1 (Clinical study)
